Buy Modafinil (Provigil) Online | Mechanism of action of the Drug | Effects of Modafinil on the Body

Buy Modafinil (Provigil) Online | Mechanism of action of the Drug | Effects of Modafinil on the Body

Buy Modafinil (Provigil) Online | Mechanism of action of the Drug | Effects of Modafinil on the Body

Modafinil (Provigil)

Modafinil belongs to the class of analeptics that includes drugs that excite the central nervous system. In the United States and Europe, it is officially used in the treatment of pathological sleepiness caused by narcolepsy. In the CIS countries, Modafinil is allowed and used recreationally to improve performance in conditions of sleep deprivation.

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Mechanism of action of the drug

Modafinil has a strong stimulating effect on the respiratory and vasomotor centers of the medulla oblongata. The drug affects the function of brain cells directly and through the system of neurotransmitters – chemicals that enhance or inhibit the transmission of nerve signals. In the hypothalamus, neuropaths are activated that implement the action of orexins, neurotransmitters responsible for regulating the sleep-wake cycle. The lack of them is diagnosed in people with narcolepsy. Other mechanisms of action of Modafinil are:

  • activation of epinephrine receptors
  • enhancing the effects of histamine and serotonin
  • reduced activity of gamma-aminobutyric acid receptors

Thus, the drug increases the effect of substances that excite the nervous system and suppresses the functions of the inhibitory mediator. Unlike methamphetamines, it does not significantly alter dopamine and serotonin transmission, so it does not cause a euphoric effect. Modafinil is assessed as a psychostimulant with a low narcotic potential, non-addictive with a single use.

Effects of Modafinil on the body

Modafinil increases tone and physical energy by suppressing the need for sleep. At the same time, patients retain or even increase their concentration, memory, ability to spatial analysis and solving logical problems. The increase in cognitive functions is most pronounced in individuals with initially reduced intelligence and a low level of education.

After administration of Modafinil increases motivation and satisfaction of the work performed. Thanks to serotonin activation, mood improves, self-confidence appears, and depression, anxiety, and irritability decrease. Many patients note that while taking the drug, they became more sociable and friendly, ready to interact with people and speak publicly.

Therapeutic use of the drug

According to the instructions, Modafinil is indicated for patients with excessive sleepiness provoked by narcolepsy, obstructive sleep apnea syndrome or circadian cycle disorders. The most common use of the drug is in the United States, where it is prescribed not only for pathological sleep disorders, but also for sleep-wake failures in night shift workers, military personnel, and pilots. According to independent surveys, doctors use Modafinil for indications that are not approved in official recommendations and instructions. It is prescribed in the complex therapy of depressive disorders, chronic fatigue syndrome, bipolar affective disorder, cerebral palsy, Parkinson’s disease, myotonic dystrophy, fibromyalgia.

Side effect

In Europe and the United States, doctors prescribe Modafinil only when necessary, since there is a high probability of side effects. The most common reactions are headache (34% of cases) and allergic reactions. The drug increases the level of histamine in the body, which leads to a variety of allergy symptoms: hives, itching and peeling of the skin, edema of the mucous membranes and soft tissues, Quincke’s edema, polymorphic erythema and other symptoms.

Modafinil increases the risk of nervous system exhaustion. Regular lack of sleep, accompanied by mental and physical stress, leads to a failure in the system of regulation. Patients develop weakness, dizziness, insomnia, and emotional instability. Other possible side effects include:

  • nausea
  • diarrhea
  • digestive disorder
  • dyspnea
  • alarm
  • heat
  • yellowness of skin and sclera

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